I've just set up this version of Drupal SQLite v6.12 on very low-memory (360MB) machine running nginx+fastcgi.  Very noticeable increase in page loads.

Is there still a performance benefit from page caching with the SQLite database layer?  Since cached content is stored in the database, caching would presumably cause the database flat file to grow in size substantially, and possiblity negate the desired effect of the caching.